William Groutas views research as an additional tool for helping students succeed in the classroom.
 
Photo: Jen Hendricks
Professor's research strives to combat the stomach flu
Dec 4, 2013 9:50 AM | Print
Share

More than 21 million cases of the stomach flu, caused by Norovirus, are reported every year in the United States.

William Groutas, Endowment Association Distinguished Professor at Wichita State, is working with his research team to create an anti-norovirus therapeutic to combat the disease.

The stomach flu can be especially harmful to immune compromised individuals, the young and elderly. And officials with the National Institutes of Health (NIH) are concerned that the virus could be used as a bio-terrorism weapon.

With support from the NIH, and in collaboration with Kansas State University and Ohio State University, Groutas and his team are focusing not on the Norovirus itself, but on blocking an enzyme that allows it to replicate.

"We have been fairly successful in identifying multiple series of compounds that inhibit an enzyme, norovirus protease, that is essential for virus replication, and we have also forged very successful collaborations with scientists at Kansas State University, who have a cell-based system for screening our compounds, and also another group at Ohio State University that has the best animal model for Norovirus infection," Groutas said.

Groutas' dedication to antiviral research, including Norovirus, stemmed from his time as a postdoctoral fellow at Cornell University where he became interested in studying the human proteases (enzymes that split proteins) responsible for the degradation of lung connective tissue in emphysema, a lung disease most often caused by smoking. While they were successful in coming up with multiple classes of compounds that were effective in inhibiting the enzymes in a test tube, there was no suitable animal model for emphysema that could be used to evaluate the compounds' effectiveness.

While it was evident that the NIH wanted them to continue their research, the lack of an appropriate animal model forced a major change in their research. About six years ago, they transitioned from studying the human enzymes and decided to leverage their expertise to design inhibitors of viral proteases, Groutas said.

The three viruses they focused on were West Nile virus, Dengue virus and Norovirus. Along with their success with Norovirus, Groutas and his team have been successful in creating inhibitors for West Nile virus and Dengue virus in collaboration with researchers at Georgetown University Medical Center.

Recently, Groutas received the Dolph Simons Award in Biomedical Sciences, part of the Higuchi-KU Endowment Research Achievement Awards.

"Groutas and his accomplishments exemplify what WSU is and what we hope it to be – a place where we can have people doing world-class research, and those are the same people who are in the class teaching the students," said David Eichhorn, Department of Chemistry professor and chair.

Groutas views his research as another teaching tool for his students.

"Engagement in research keeps a teacher up to date and on the cutting edge of their field, and the enthusiasm for research is manifested in the classroom," Groutas said.

Created on Dec 4, 2013 9:50 AM; Last modified on Dec 20, 2013 12:32 PM
#
HEADLINES RSS Feed
Koch Global Trading Center officially dedicated
Rhatigan Renewal revives campus life
WSU dedicates building named for former president
Innovative splint developed by WSU researchers
WSU expansion will support job growth, innovation
Wichita State Musical Theater presents 'The Spitfire Grill'
Economic Outlook Conference, Oct. 9
History Department special presentation
Workshop to prepare students for ACT
Nursing student workshop to be held at WSU
WSU hosting 'Writing Now, Reading Now' series
WSU to host ACT Math Workshop
David Cabela to speak at WSU forum
Constitution Day activity at WSU
The Elliott School of Communication turns 25
Kansas Council for Economic Education receives grant
Ray to discuss photography at reception
Students, community welcome at WSU outdoor movie
AQR holiday travel forecast: Book early
CEDBR now offers indicators in optimal format
Students feel at home in Shocker Hall
Tree planting honors WSU's KBOR anniversary
WSU School of Nursing one of 100 schools chosen
Innovation helps WSU School of Nursing reach students
© 1995-2014 Wichita State University. All rights reserved.
Valid HTML 401