Developmental Systems Biology


Academic Interests and Expertise

My lab studies gene regulatory networks and cell physiological mechanisms that direct animal development.  We use the fruit fly, Drosophila melanogaster, as a model organism.  Our multidisciplinary work is composed of two research programs and uses methods from genetics, cell biology, biochemistry, molecular biology, and bioinformatics. 

  • Developmental Dynamics-The questions that drive our developmental dynamics research projects aim to determine the key components of Drosophila matrisome that direct tubulogenesis in the embryo.  Model tubular organs studied include (i) the embryonic salivary gland, (ii) trachea, and (iii) the heart.
  • Integrative Systems Biology-The questions that motivate our systems biology initiative explore the effects of exercise physiology on stem cell dynamics.  We ask how exercise affects stem cell health by focusing on the cellular and extracellular mechanisms that calibrate stem cell homeostasis in response to systemic training adaptations. 
Areas of Teaching Interest
  • Teaching Interests:  Cell and Developmental Biology, Evolutionary Developmental Biology of Organs and Organ Systems.
  • Teaching Experience:  Cell Physiology (Johns Hopkins University School of Medicine); Neurophysiology (University of Kansas School of Medicine)
  • WSU Courses:  Biol 497/797 (Fall 2022)

Research Articles, Reviews, and Editorials

  • Ribbon boosts ribosomal protein gene expression to coordinate organ form and function
    Journal of Cell Biology (2022) Apr 4; 221(4) DOI:  10.1083/jcb.20211073
    Loganathan, R., Levings, D.C., Kim, J.H., Wells, M.B., Chiu, H., Wu, H., Slattery, M., Andrew, D.J.
  • Secrets of secretion-how studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function. 

    Current Topics in Developmental Biology (2021), Volume 143.
    Loganathan, R., J.H. Wells, M.B., Andrew, D.J.

  • Extracellular Matrix Dynamics in Biology, BIoengineering, and Pathology
    Frontiers in Cell and Developmental Biology (2020).  Aug 21; 8: 759.
    Loganathan, R., Little, C.D., Rongish, B.J.
  • Extracellular matrix dynamics in tubulogenesis
    Cell Signal (2020), 72: 109619.
    Loganathan, R., Rongish, B.J., Little, C.D.
  • CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators
    Traffic (2020, 21 (9), 560-577.
    Johnson, D.M., Wells, M.B., Fox, R., Lee, J.S., Loganathan, R., Levings, D., Bastien, A., Slattery, M., Andrew, D.J.
  • Organogenesis of the Drosophila respiratory system 
    Organogenetic gene networks (2016), pp. 151-211.
    Loganathan, R., Cheng, Y. L., Andrew, D.J.
  • Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression 
    Developmental Biology (2016), 409 (1), 234-50.
    Loganathan, R., Lee, J.S., Wells, M.B., Grevengoed, E., Slattery, M., Andrew, D.J.
  • Extracellular matrix motion and early morphogenesis
    Development (2016), 143 (12), 2056-2065.
    Loganathan, R., Rongish, B.J., Smith, C.M., Filla, M.B., Czirok, A., Bénazéraf, B., Little, C.D.
  • Identification of emergent motion compartments in the amniote embryo
    Organogenesis (2014), 10 (4), 350-364.
    Loganathan, R., Little, C.D., Joshi, P., Filla, M.B., Cheuvront, T.J., Lansford, R., Rongish, B.J.
  • The role of sleep in motor learning
    Journal of Postdoctoral Research (2014), 2(4), 18-29.
    Loganathan, R.
  • Spatial anisotropies and temporal fluctuations in the extracellular matrix network texture during early embryogenesis
    PLOS ONE (2012), 7 (5): e38266.
    Loganathan, R., Potetz, B.R., Rongish, B.J., Little, C.D. (2012).
  • Exercise induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol
    Journal of Applied Physiology (2012), 113 (5), 817-826.
    Loganathan, R., Novikova, L., Boulatnikov, I., Smirnova, I.V.
  • Time–dependent alterations in rat macrovessels with type 1 diabetes
    Experimental Diabetes Research (2012), 278620.
    Searls, Y., Smirnova, I.V., Vanhoose, L., Fegley, B., Loganathan, R., Stehno-Bittel, L.
  • Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat
    Cardiovascular Diabetology (2010), 9:56.
    VanHoose, L., Sawers, Y., Loganathan, R., Vacek, J.L., Stehno-Bittel, L., Novikova, L., Al-Jarrah, M., Smirnova, I.V.
  • Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type1 diabetes due to the direct effects of hyperglycemia
    Cardiovascular Diabetology (2010), 9:8.
    Searls, Y.M., Loganathan, R., Smirnova, I.V., Stehno-Bittel, L.
  • Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses
    Journal of Applied Physiology (2007), 102 (2), 665-672.
    Loganathan, R., Bilgen, M., Al-Hafez, B., Zhero, S.V., Alenezy, M.D., Smirnova, I.V.
  • Exercise induced benefits in individuals with type 1 diabetes
    Physical Therapy Reviews (2006), 11, 77-89.
    Loganathan, R., Searls, Y., Smirnova, I.V., Stehno-Bittel, L.
  • Cardiac dysfunction in the diabetic rat: Quantitative evaluation using high resolution magnetic resonance imaging
    Cardiovascular Diabetology (2006), 5:7.
    Loganathan, R., Bilgen, M., Al-Hafez, B., Alenezy, M.D., Smirnova, I.V.
  • Characterization of alterations in diabetic myocardial tissue using high resolution MRI
    International Journal of Cardiovascular Imaging (2006), 22 (1), 81-90.
    Loganathan, R., Bilgen, M., Al-Hafez, B., Smirnova I.V.
  • CXCL-10 induced cell death in neurons: Role of calcium dysregulation
    European Journal of Neuroscience (2006), 23 (4), 957-64.
    Sui, Y., Stehno-Bittel, L., Li, S., Loganathan, R., Pinson, D., Narayan, O., Buch, S.


  • Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology (Volume-II)
    Frontiers in Cell and Developmental Biology (In progress).
    Loganathan, R., Yanagisawa, H., Little, C. D., Gentleman, E., Weiss, J., Eds.
  • Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology (Volume-I)
    Frontiers in Cell and Developmental Biology (2020). doi: 10.3389/978-2-88966-119-0 Loganathan, R., Little, C. D., Rongish, B. J., Eds.
Professional Experience

2022 – present: Assistant Professor, Wichita State University
2018 – 2022: Research Associate, Johns Hopkins University
2011 – 2018: Research Fellow, Johns Hopkins University


2021: Johns Hopkins Core Coins Pilot Grant for Genome Research

2016: Johns Hopkins Core Coins Pilot Grant for Proteomics Research

2006: American Heart Association Predoctoral Fellowship

Areas of Service

Editorial Board – Frontiers in Cell and Developmental Biology (section on cell growth and division)

Guest Associate Editor – Frontiers in Cell and Developmental Biology (section on cell adhesion and migration)

Session Co-Chair – “Patterning, Morphogenesis, and Organogenesis,” 63rd Annual Drosophila Meeting, Genetics Society of America

Session Co-Chair – “The Dynamic Extracellular Matrix,” 2022 Annual Meeting of the American Association for Anatomy

Invited Panelist – The Future of Research Symposium (2019) by the University of Maryland/Johns Hopkins University/Elsevier

Additional Information
Institution Degree Year Program (Field of Study)
University of Kansas Medical Center PhD 2007 Rehabilitation Science
(Cardiovascular Pathophysiology)
University of Kansas MS 2011 Electrical Engineering
(Developmental Biology)
Government Institute of Rehabilitation Medicine-Madras Medical College BPT 2000 Physical Therapy